局灶性黑质损伤后的偏侧帕金森综合征和左旋多巴诱导的运动障碍
Hemiparkinsonism and levodopa-induced dyskinesias after focal nigral lesion.
作者信息
Růzicka Evzen, Urgosík Dusan, Jech Robert, Roth Jan, Vymazal Josef, Mecír Petr, Vladyka Vilibald
机构信息
Movement Disorders Center, 1st Medical Faculty, Charles University, Katerinská 30, CZ-120 100 Prague, Czech Republic.
出版信息
Mov Disord. 2005 Jun;20(6):759-62. doi: 10.1002/mds.20453.
PMID:15782419
Abstract
We present a patient with tremor-dominant hemiparkinsonism after a focal lesion to the substantia nigra. An excellent response to levodopa was complicated by rapid development of motor fluctuations and disabling dyskinesias. Stereotactic thalamotomy resulted in a persistent extinction of parkinsonism and of dyskinesias along with stopping dopaminergic treatment.
摘要
我们报告一名黑质局灶性病变后出现以震颤为主的偏侧帕金森综合征患者。对左旋多巴有良好反应，但因运动波动迅速发展和致残性异动症而变得复杂。立体定向丘脑切开术导致帕金森综合征和异动症持续消失，同时停止多巴胺能治疗。
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