Dubileĭ S A, Ignatova A N, Shemiakin I G
Mol Gen Mikrobiol Virusol. 2005(1):3-7.
Above two million people annually die worldwide of tuberculosis. There has been a serious uptrend in the tuberculosis morbidity observed during the recent decade in Russia. The growing prevalence of drug-resistant strains of pathogens is highly dangerous. A timely diagnosis reduces significantly the risk of epidemics. The use of molecular methods cuts the time of tuberculosis diagnosis, including its resistant forms, from several weeks to several days. The presented survey contains a discussion of modem methods used for identification of Mycobacterium tuberculosis resistance to the main anti-TB drugs.
全球每年有超过两百万人死于肺结核。在俄罗斯,近十年来肺结核发病率呈严重上升趋势。病原体耐药菌株的日益流行极具危险性。及时诊断可显著降低疫情风险。分子方法的应用将肺结核(包括耐药形式)的诊断时间从数周缩短至数天。本综述讨论了用于鉴定结核分枝杆菌对主要抗结核药物耐药性的现代方法。