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[早期胃癌的有限手术联合区域淋巴结清扫——一种可靠的胃癌前哨淋巴结活检方法]

[Limited surgery for early gastric cancer using lymphatic basin dissection--a sure method of sentinel node biopsy for gastric cancer].

作者信息

Kinami Shinichi, Miwa Koichi, Ishii Kaname, Miyashita Tomoharu, Fushida Sachio, Fujimura Takashi, Ohta Tetsuo

机构信息

Dept. of Gastroenterologic Surgery, Division of Cancer Medicine, Graduate School of Medicine, Kanazawa University, Japan.

出版信息

Gan To Kagaku Ryoho. 2005 Mar;32(3):405-10.

Abstract

The results of our sentinel node biopsy for early-stage gastric cancer had a high predictive value for nodal metastasis, with a sensitivity of 85% (34/40) and an accuracy of 98% (259/265). Therefore, sentinel node biopsy is expected to be decided as an adaptation of limited surgery for early gastric cancer. However, there were two serious problems in sentinel node biopsy for gastric cancer; one was the great difficulty of sentinel node detection and biopsy in the operative field, and the other was the possibility of false negative cases in the frozen section diagnosis. To solve these problems, we developed lymphatic basin dissection, a new technique suitable for sentinel node biopsy of gastric cancer. The lymphatic basin is an own lymphatic components dyed in blue in the dye method. In the lymphatic basin dissection method, sentinel nodes are detected and harvested at the back table after en bloc dissection of the lymphatic basins. Lymphatic basin dissection is an excellent method because of the certainty in sentinel node biopsy, and the sure back-up dissection. Lymphatic basin dissection and following limited surgery was performed on 143 patients for early-stage gastric cancer in our hospital. No patient had a recurrence of gastric cancer; 9 patients died of other diseases, and the other 134 survived.

摘要

我们对早期胃癌进行前哨淋巴结活检的结果对淋巴结转移具有较高的预测价值,敏感性为85%(34/40),准确性为98%(259/265)。因此,前哨淋巴结活检有望被确定为早期胃癌有限手术的一种适应证。然而,胃癌前哨淋巴结活检存在两个严重问题:一是在手术视野中前哨淋巴结检测和活检难度极大,另一个是冰冻切片诊断中存在假阴性病例的可能性。为了解决这些问题,我们开发了淋巴流域清扫术,这是一种适用于胃癌前哨淋巴结活检的新技术。淋巴流域是在染料法中被染成蓝色的自身淋巴成分。在淋巴流域清扫术中,在整块切除淋巴流域后于手术后台检测并获取前哨淋巴结。淋巴流域清扫术是一种出色的方法,因为前哨淋巴结活检具有确定性,且有可靠的补救性清扫。我院对143例早期胃癌患者进行了淋巴流域清扫术及后续的有限手术。没有患者出现胃癌复发;9例患者死于其他疾病,其余134例存活。

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