Evolution of a retinoma case in 21 years.

A 35-year-old man was observed during a 21-year period with fundus color photography, fluorescein angiography, and B-scan ultrasonography for a presumed retinoma detected in his left eye during routine ophthalmoscopy in 1982. The patient was a carrier of the 13q14 retinoblastoma gene. His retinal lesion remained stable during the follow-up period without signs of malignant transformation. Retinomas are most commonly observed in patients with retinoblastoma and their relatives. In this case, none of the patient's parents, siblings, or children had evidence of a retinal tumor. Photographic documentation of the nonprogressive nature of this presumed retinoma is provided and demonstrates the absence of growth.