Podnar Simon, Zalewska Ewa, Hausmanowa-Petrusewicz Irena
Institute of Clinical Neurophysiology, Division of Neurology, University Medical Center Ljubljana, SI-1525 Ljubljana, Slovenia.
Clin Neurophysiol. 2005 Apr;116(4):948-56. doi: 10.1016/j.clinph.2004.11.003. Epub 2004 Dec 10.
Motor unit potential (MUP) morphology can be quantified using parameters describing electrophysiological size and shape (complexity). Traditionally, MUP complexity has been estimated using parameters number of phases and turns. Recently, 'irregularity coefficient' (IR), measuring the length of the MUP curve normalized with its amplitude, has been introduced. The aim of this study was to evaluate IR in the external anal sphincter muscle.
Sensitivity was examined in 61 patients with chronic cauda equina lesions, and specificity in 75 controls using a standard concentric EMG needle and EMG system with multi-MUP analysis.
When evaluated separately the sensitivity of IR was 16% lower, and specificity 5% higher compared to number of turns, with both differences decreasing to only 2 and 1%, respectively, when each of these parameters was added to MUP area and duration.
Our present results suggest that IR provides a similar diagnostic usefulness, but a more appropriate description of MUP complexity compared to traditional MUP parameters.
IR seems to be suitable to complement one of MUP parameters measuring electrophysiological MUP size in the future quantitative EMG.
运动单位电位（MUP）形态可通过描述电生理大小和形状（复杂性）的参数进行量化。传统上，MUP复杂性是使用相位和转折数等参数来估计的。最近，引入了“不规则系数”（IR），即测量MUP曲线长度与其幅度的归一化值。本研究的目的是评估肛门外括约肌中的IR。
使用标准同心肌电图针和具有多MUP分析功能的肌电图系统，对61例慢性马尾神经损伤患者进行敏感性检查，并对75例对照者进行特异性检查。
单独评估时，与转折数相比，IR的敏感性低16%，特异性高5%；当将这些参数中的每一个与MUP面积和时限相加时，两者的差异分别降至仅2%和1%。
我们目前的结果表明，与传统的MUP参数相比，IR具有相似的诊断价值，但对MUP复杂性的描述更合适。
在未来的定量肌电图中，IR似乎适合作为测量电生理MUP大小的MUP参数之一的补充。
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