Baunez Christelle, Dias Carine, Cador Martine, Amalric Marianne
Laboratoire de Neurobiologie de la Cognition, Unité Mixte de Recherche 6155 Centre National de la Recherche Scientifique Université de Provence, 13402 Marseille Cedex 20, France.
Nat Neurosci. 2005 Apr;8(4):484-9. doi: 10.1038/nn1429. Epub 2005 Mar 27.
A challenge in treating drug addicts is preventing their pathological motivation for the drug without impairing their general affective state toward natural reinforcers. Here we have shown that discrete lesions of the subthalamic nucleus greatly decreased the motivation of rats for cocaine while increasing it for food reward. The subthalamic nucleus, a key structure controlling basal ganglia outputs, is therefore able to oppositely modulate the effect of 'natural' rewards and drugs of abuse on behavior. Modulating the activity of the subthalamic nucleus might prove to be a new target for the treatment of cocaine addiction.
治疗吸毒成瘾者面临的一个挑战是，在不损害他们对自然强化物的一般情感状态的情况下，阻止他们对毒品产生病理性动机。我们在此表明，丘脑底核的离散性损伤极大地降低了大鼠对可卡因的动机，同时增加了它们对食物奖励的动机。丘脑底核作为控制基底神经节输出的关键结构，因此能够反向调节“自然”奖励和滥用药物对行为的影响。调节丘脑底核的活动可能会成为治疗可卡因成瘾的一个新靶点。
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