水溶性合成四肽形成超分子三螺旋的X射线晶体学特征

X-ray crystallographic signature of supramolecular triple helix formation from a water soluble synthetic tetrapeptide.

作者信息

Das Apurba Kumar, Haldar Debasish, Hegde Raghurama P, Shamala N, Banerjee Arindam

机构信息

Department of Physics, Indian Institute of Science, Bangalore-560012, India.

出版信息

Chem Commun (Camb). 2005 Apr 14(14):1836-8. doi: 10.1039/b417726f. Epub 2005 Feb 16.

DOI:10.1039/b417726f

PMID:15795759

Abstract

Single crystal X-ray diffraction studies on the water soluble, synthetic tetrapeptide Tyr(1)-Aib(2)-Tyr(3)-Val(4) with a non-coded amino acid residue (Aib: [small alpha]-amino isobutyric acid) reveal that the peptide adopts an "S"-shaped molecular structure which self-assembles to form a supramolecular triple helix using various non-covalent interactions including water mediated hydrogen bonds in the solid state.

摘要

对含有非编码氨基酸残基（Aib：α-氨基异丁酸）的水溶性合成四肽Tyr(1)-Aib(2)-Tyr(3)-Val(4)进行的单晶X射线衍射研究表明，该肽采用“S”形分子结构，在固态下通过包括水介导的氢键在内的各种非共价相互作用自组装形成超分子三螺旋。