Zhu Jia-Yuan, Zhu Bin, Li Xin-Qiang, Tang Bing, Zhong Zhan-Fang, Chen Dong, Zhang Wei
Department of Burns, The First Affiliated Hospital, Medical School of Sun Yat-sen University, Guangzhou 510080, P.R. China.
Zhonghua Shao Shang Za Zhi. 2005 Feb;21(1):21-3.
To evaluate the effect of mixed composite skin graft on the deep partial thickness burn wounds after tangential excision in burn patients.
Tangential excision was performed in 30 extremities of 23 burn patients within 3 postburn days (PBDs). Then large pieces of homologous acellular dermal matrix were grafted onto the superficial fascia with razor thin autoskin on top of them. The survival rate of skin grafts, the appearance and the functional recovery of the extremities were observed on 10 to 12 post operative day (POD). Skin samples from a healed wound of a patient were harvested three months after the injury for pathologic examination.
The survival rate of the composite skin grafts was 93%. Necrosis was encountered in 7% of the grafts in the lower extremities due to the poor fixation of the grafts leading to separation of autologous skin and the dermal template, and also due to infection resulting in lysis of the grafts. The grafted skin was excellent in the appearance and elasticity, and function of the injured extremities recovered well after grafting after 3 - 6 months of follow-up. Epidermal and dermal texture was also good as shown by pathologic examination.
Mixed composite skin grafting after early tangential excision might be an ideal and effective method in the management of deep partial thickness burn wounds.
评估混合复合皮移植对烧伤患者削痂术后深Ⅱ度烧伤创面的效果。
对23例烧伤患者的30个肢体在伤后3天内进行削痂,然后将大片同种异体脱细胞真皮基质移植于浅筋膜上,并在其上面覆盖极薄的自体皮。于术后10至12天观察皮片成活率、肢体外观及功能恢复情况。伤后3个月取患者愈合创面的皮肤标本进行病理检查。
复合皮移植成活率为93%。下肢7%的移植皮片出现坏死,原因是移植皮片固定不佳导致自体皮与真皮模板分离,以及感染导致移植皮片溶解。移植皮肤外观及弹性良好,随访3至6个月后,伤肢功能恢复良好。病理检查显示表皮和真皮结构也良好。
早期削痂后行混合复合皮移植可能是治疗深Ⅱ度烧伤创面的一种理想且有效的方法。