血管紧张素转换酶基因的插入/缺失多态性与对血管紧张素转换酶抑制剂的依从性
Insertion/deletion polymorphism of the ACE gene and adherence to ACE inhibitors.
作者信息
Schelleman H, Klungel O H, van Duijn C M, Witteman J C M, Hofman A, de Boer A, Stricker B H Ch
机构信息
Department of Epidemiology & Biostatistics, Erasmus MC, Rotterdam, The Netherlands.
出版信息
Br J Clin Pharmacol. 2005 Apr;59(4):483-5. doi: 10.1111/j.1365-2125.2004.02332.x.
Abstract
AIMS
We investigated whether the insertion/deletion (I/D) polymorphism of the ACE gene modified the adherence to ACE inhibitors as measured by the discontinuation of an ACE inhibitor, or addition of another antihypertensive drug.
METHODS
This was a cohort study among 239 subjects who started ACE inhibitor therapy. A Cox proportional hazard model was used to calculate relative risk (RR).
RESULTS
During follow-up there was no significant difference between subjects with the DD, ID or II genotype (DD vs II; RR = 1.17, 95%CI: 0.78, 1.77 and ID vs II; RR = 1.06, 95%CI: 0.73, 1.55) in adherence.
CONCLUSIONS
The I/D polymorphism of the ACE gene does not influence the adherence to ACE inhibitors.
摘要
目的
我们研究了血管紧张素转换酶（ACE）基因的插入/缺失（I/D）多态性是否会通过停用ACE抑制剂或添加另一种抗高血压药物来衡量对ACE抑制剂的依从性产生影响。
方法
这是一项针对239名开始接受ACE抑制剂治疗的受试者的队列研究。采用Cox比例风险模型计算相对风险（RR）。
结果
在随访期间，DD、ID或II基因型受试者（DD与II相比；RR = 1.17，95%置信区间：0.78，1.77；ID与II相比；RR = 1.06，95%置信区间：0.73，1.55）在依从性方面没有显著差异。
结论
ACE基因的I/D多态性不影响对ACE抑制剂的依从性。
相似文献
1
Insertion/deletion polymorphism of the ACE gene and adherence to ACE inhibitors.血管紧张素转换酶基因的插入/缺失多态性与对血管紧张素转换酶抑制剂的依从性
Br J Clin Pharmacol. 2005 Apr;59(4):483-5. doi: 10.1111/j.1365-2125.2004.02332.x.
2
Drug-gene interaction between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and antihypertensive therapy.血管紧张素转换酶基因插入/缺失多态性与降压治疗之间的药物-基因相互作用。
Ann Pharmacother. 2006 Feb;40(2):212-8. doi: 10.1345/aph.1G316. Epub 2006 Jan 31.
3
Reduction of pneumonia risk by an angiotensin I-converting enzyme inhibitor in elderly Japanese inpatients according to insertion/deletion polymorphism of the angiotensin I-converting enzyme gene.根据血管紧张素I转换酶基因的插入/缺失多态性，血管紧张素I转换酶抑制剂对日本老年住院患者肺炎风险的降低作用
Am J Hypertens. 2005 Oct;18(10):1353-9. doi: 10.1016/j.amjhyper.2005.04.020.
4
A study of the relationships between angiotensin- converting enzyme gene, chymase gene polymorphisms, pharmacological treatment with ACE inhibitor and regression of left ventricular hypertrophy in essential hypertension patients treated with benazepril.一项关于苯那普利治疗的原发性高血压患者中血管紧张素转换酶基因、糜酶基因多态性、血管紧张素转换酶抑制剂药物治疗与左心室肥厚消退之间关系的研究。
Ann Hum Biol. 2005 Jan-Feb;32(1):30-43. doi: 10.1080/03014460400027458.
5
Pharmacogenetic interactions between angiotensin-converting enzyme inhibitor therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure.充血性心力衰竭患者中血管紧张素转换酶抑制剂治疗与血管紧张素转换酶基因缺失多态性之间的药物遗传学相互作用。
J Am Coll Cardiol. 2004 Nov 16;44(10):2019-26. doi: 10.1016/j.jacc.2004.08.048.
6
Pharmacogenetic interactions of three candidate gene polymorphisms with ACE-inhibitors or beta-blockers and the risk of atherosclerosis.三种候选基因多态性与血管紧张素转换酶抑制剂或β受体阻滞剂的药物遗传学相互作用及动脉粥样硬化风险
Br J Clin Pharmacol. 2007 Jul;64(1):57-66. doi: 10.1111/j.1365-2125.2007.02848.x. Epub 2007 Feb 12.
7
Angiotensin converting enzyme insertion/deletion polymorphism and the risk of heart failure in hypertensive subjects.血管紧张素转换酶插入/缺失多态性与高血压患者心力衰竭风险
Eur Heart J. 2004 Dec;25(23):2143-8. doi: 10.1016/j.ehj.2004.08.026.
8
Vascular effects of quinapril completely depend on ACE insertion/deletion polymorphism.喹那普利的血管效应完全取决于血管紧张素转换酶插入/缺失多态性。
J Renin Angiotensin Aldosterone Syst. 2004 Sep;5(3):130-4. doi: 10.3317/jraas.2004.029.
9
10
Relation between the angiotensin-converting enzyme insertion/deletion polymorphism and blood pressure in Japanese male subjects.日本男性受试者血管紧张素转换酶插入/缺失多态性与血压的关系。
J Hum Hypertens. 2003 Oct;17(10):713-8. doi: 10.1038/sj.jhh.1001601.
引用本文的文献
1
The Effect of Angiotensin Converting Enzyme (ACE) I/D Polymorphism on Atherosclerotic Cardiovascular Disease and Cardiovascular Mortality Risk in Non-Hemodialyzed Chronic Kidney Disease: The Mediating Role of Plasma ACE Level.血管紧张素转换酶（ACE）I/D 多态性对非透析慢性肾脏病患者动脉粥样硬化性心血管疾病及心血管死亡风险的影响：血浆 ACE 水平的中介作用。
Genes (Basel). 2022 Jun 23;13(7):1121. doi: 10.3390/genes13071121.
2
Role of ACE I/D gene polymorphisms on the effect of ramipril in inflammatory response and myocardial injury in patients undergoing coronary artery bypass grafts.血管紧张素转换酶I/D基因多态性对雷米普利在冠状动脉搭桥术患者炎症反应及心肌损伤中作用的影响
Eur J Clin Pharmacol. 2014 Dec;70(12):1443-51. doi: 10.1007/s00228-014-1751-5. Epub 2014 Sep 27.
3
Progress toward genetic tailoring of heart failure therapy.心力衰竭治疗基因定制方面的进展。
Curr Opin Mol Ther. 2010 Jun;12(3):294-304.
本文引用的文献
1
Patterns of hypertension management in Italy: results of a pharmacoepidemiological survey on antihypertensive therapy. Scientific Committee of the Italian Pharmacoepidemiological Survey on Antihypertensive Therapy.意大利高血压管理模式：一项关于抗高血压治疗的药物流行病学调查结果。意大利抗高血压治疗药物流行病学调查科学委员会
J Hypertens. 2000 Nov;18(11):1691-9. doi: 10.1097/00004872-200018110-00023.
2
Is there an association between angiotensin-converting enzyme gene variants and chronic nonproductive cough?
Chest. 2000 Oct;118(4):1091-4. doi: 10.1378/chest.118.4.1091.
3
Predicting response to chronic antihypertensive treatment with fosinopril: the role of angiotensin-converting enzyme gene polymorphism.
Cardiovasc Drugs Ther. 2000 Aug;14(4):427-32. doi: 10.1023/a:1007820401377.
4
Genomic medicine and the future of health care.基因组医学与医疗保健的未来。
Science. 2000 Mar 17;287(5460):1977-8. doi: 10.1126/science.287.5460.1977.
5
Relationship between the response to the angiotensin converting enzyme inhibitor imidapril and the angiotensin converting enzyme genotype.血管紧张素转换酶抑制剂咪达普利的反应与血管紧张素转换酶基因型之间的关系。
Am J Hypertens. 1997 Aug;10(8):951-5. doi: 10.1016/s0895-7061(97)00121-0.
6
Renin-angiotensin system gene polymorphisms influence blood pressure and the response to angiotensin converting enzyme inhibition.肾素-血管紧张素系统基因多态性影响血压以及对血管紧张素转换酶抑制的反应。
J Hypertens. 1995 Dec;13(12 Pt 2):1602-9.
7
Prediction of patient responses to antihypertensive drugs using genetic polymorphisms: investigation of renin-angiotensin system genes.利用基因多态性预测患者对抗高血压药物的反应：肾素-血管紧张素系统基因研究
J Hypertens. 1996 Feb;14(2):259-62. doi: 10.1097/00004872-199602000-00016.
8
Angiotensin-I-converting enzyme gene polymorphism and susceptibility to cough.
Lancet. 1994 Feb 5;343(8893):354. doi: 10.1016/s0140-6736(94)91190-8.
9
A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischemic heart disease.血管紧张素转换酶基因多态性与缺血性心脏病风险的前瞻性评估。
N Engl J Med. 1995 Mar 16;332(11):706-11. doi: 10.1056/NEJM199503163321103.
10
An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.血管紧张素I转换酶基因中的插入/缺失多态性可解释血清酶水平一半的变异。
J Clin Invest. 1990 Oct;86(4):1343-6. doi: 10.1172/JCI114844.
Zotero 插件