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Patterns of hypertension management in Italy: results of a pharmacoepidemiological survey on antihypertensive therapy. Scientific Committee of the Italian Pharmacoepidemiological Survey on Antihypertensive Therapy.意大利高血压管理模式：一项关于抗高血压治疗的药物流行病学调查结果。意大利抗高血压治疗药物流行病学调查科学委员会
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Is there an association between angiotensin-converting enzyme gene variants and chronic nonproductive cough?
Chest. 2000 Oct;118(4):1091-4. doi: 10.1378/chest.118.4.1091.
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Predicting response to chronic antihypertensive treatment with fosinopril: the role of angiotensin-converting enzyme gene polymorphism.
Cardiovasc Drugs Ther. 2000 Aug;14(4):427-32. doi: 10.1023/a:1007820401377.
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Genomic medicine and the future of health care.基因组医学与医疗保健的未来。
Science. 2000 Mar 17;287(5460):1977-8. doi: 10.1126/science.287.5460.1977.
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Relationship between the response to the angiotensin converting enzyme inhibitor imidapril and the angiotensin converting enzyme genotype.血管紧张素转换酶抑制剂咪达普利的反应与血管紧张素转换酶基因型之间的关系。
Am J Hypertens. 1997 Aug;10(8):951-5. doi: 10.1016/s0895-7061(97)00121-0.
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Renin-angiotensin system gene polymorphisms influence blood pressure and the response to angiotensin converting enzyme inhibition.肾素-血管紧张素系统基因多态性影响血压以及对血管紧张素转换酶抑制的反应。
J Hypertens. 1995 Dec;13(12 Pt 2):1602-9.
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Prediction of patient responses to antihypertensive drugs using genetic polymorphisms: investigation of renin-angiotensin system genes.利用基因多态性预测患者对抗高血压药物的反应：肾素-血管紧张素系统基因研究
J Hypertens. 1996 Feb;14(2):259-62. doi: 10.1097/00004872-199602000-00016.
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Angiotensin-I-converting enzyme gene polymorphism and susceptibility to cough.
Lancet. 1994 Feb 5;343(8893):354. doi: 10.1016/s0140-6736(94)91190-8.
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A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischemic heart disease.血管紧张素转换酶基因多态性与缺血性心脏病风险的前瞻性评估。
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An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.血管紧张素I转换酶基因中的插入/缺失多态性可解释血清酶水平一半的变异。
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血管紧张素转换酶基因的插入/缺失多态性与对血管紧张素转换酶抑制剂的依从性

Insertion/deletion polymorphism of the ACE gene and adherence to ACE inhibitors.

作者信息

Schelleman H, Klungel O H, van Duijn C M, Witteman J C M, Hofman A, de Boer A, Stricker B H Ch

机构信息

Department of Epidemiology & Biostatistics, Erasmus MC, Rotterdam, The Netherlands.

出版信息

Br J Clin Pharmacol. 2005 Apr;59(4):483-5. doi: 10.1111/j.1365-2125.2004.02332.x.

DOI:10.1111/j.1365-2125.2004.02332.x
PMID:15801945
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1884810/
Abstract

AIMS

We investigated whether the insertion/deletion (I/D) polymorphism of the ACE gene modified the adherence to ACE inhibitors as measured by the discontinuation of an ACE inhibitor, or addition of another antihypertensive drug.

METHODS

This was a cohort study among 239 subjects who started ACE inhibitor therapy. A Cox proportional hazard model was used to calculate relative risk (RR).

RESULTS

During follow-up there was no significant difference between subjects with the DD, ID or II genotype (DD vs II; RR = 1.17, 95%CI: 0.78, 1.77 and ID vs II; RR = 1.06, 95%CI: 0.73, 1.55) in adherence.

CONCLUSIONS

The I/D polymorphism of the ACE gene does not influence the adherence to ACE inhibitors.

摘要

目的

我们研究了血管紧张素转换酶（ACE）基因的插入/缺失（I/D）多态性是否会通过停用ACE抑制剂或添加另一种抗高血压药物来衡量对ACE抑制剂的依从性产生影响。

方法

这是一项针对239名开始接受ACE抑制剂治疗的受试者的队列研究。采用Cox比例风险模型计算相对风险（RR）。

结果

在随访期间，DD、ID或II基因型受试者（DD与II相比；RR = 1.17，95%置信区间：0.78，1.77；ID与II相比；RR = 1.06，95%置信区间：0.73，1.55）在依从性方面没有显著差异。

结论

ACE基因的I/D多态性不影响对ACE抑制剂的依从性。