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丙型肝炎病毒感染患者肝组织中的线粒体DNA耗竭:HIV感染的促成作用?

Mitochondrial DNA depletion in liver tissue of patients infected with hepatitis C virus: contributing effect of HIV infection?

作者信息

Bäuerle J, Laguno M, Mauss S, Mallolas J, Murillas J, Miquel R, Schmutz G, Setzer B, Gatell J M, Walker U A

机构信息

Department of Clinical Immunology, Medizinische Universitätsklinik, Freiburg, Germany.

出版信息

HIV Med. 2005 Mar;6(2):135-9. doi: 10.1111/j.1468-1293.2005.00276.x.

Abstract

OBJECTIVES

It has been suggested that chronic hepatitis C virus (HCV) infection depletes mitochondrial DNA (mtDNA) in the liver. Because decreased mtDNA levels were also found in humans infected with HIV, we investigated whether HIV may have aggravated hepatic mtDNA depletion in individuals with HCV infection.

METHODS

In this cross-sectional study, liver biopsies were performed in a total of 40 individuals prior to any antiviral therapy. The individuals were recruited from the Hospital Clinic, Barcelona and the HIV Centre, Dusseldorf. Seventeen patients were negative for HIV and HCV and were biopsied for liver enzyme elevation of unknown cause (controls), 14 individuals had chronic HCV but no HIV infection, and nine subjects were coinfected with both viruses. mtDNA and liver histology were centrally assessed.

RESULTS

The groups did not differ with respect to age, gender, liver function tests and HCV viral load, where applicable. mtDNA levels were decreased by 19% in the HCV-monoinfected group (P=0.03) and by 27% in the HIV/HCV-coinfected subjects (P=0.02) compared to controls. The mtDNA content, however, did not differ between individuals with HCV monoinfection and HCV/HIV coinfection (P=0.75). The degrees of liver fibrosis, inflammatory activity or steatosis did not correlate with mtDNA content.

CONCLUSIONS

Liver mtDNA content is reduced in both HCV-monoinfected and HIV/HCV-coinfected patients. Under the limitations of our study, we could demonstrate only a slight trend towards more pronounced mtDNA depletion in HIV/HCV-coinfected subjects.

摘要

目的

有人提出慢性丙型肝炎病毒(HCV)感染会使肝脏中的线粒体DNA(mtDNA)减少。由于在感染HIV的人群中也发现mtDNA水平降低,我们研究了HIV是否会加重HCV感染个体的肝脏mtDNA耗竭。

方法

在这项横断面研究中,对40名个体在接受任何抗病毒治疗之前进行了肝活检。这些个体来自巴塞罗那医院诊所和杜塞尔多夫HIV中心。17名患者HIV和HCV均为阴性,因不明原因的肝酶升高接受活检(对照组),14名个体患有慢性HCV但未感染HIV,9名受试者同时感染了这两种病毒。对mtDNA和肝脏组织学进行集中评估。

结果

在适用的情况下,各组在年龄、性别、肝功能检查和HCV病毒载量方面没有差异。与对照组相比,HCV单感染组的mtDNA水平降低了19%(P=0.03),HIV/HCV合并感染组降低了27%(P=0.02)。然而,HCV单感染个体和HCV/HIV合并感染个体之间的mtDNA含量没有差异(P=0.75)。肝纤维化、炎症活动或脂肪变性程度与mtDNA含量无关。

结论

HCV单感染和HIV/HCV合并感染患者的肝脏mtDNA含量均降低。在我们研究的局限性下,我们仅能证明HIV/HCV合并感染受试者中mtDNA耗竭更明显的轻微趋势。

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