Vallone Paolo, D'Angelo Roberto, Filice Salvatore, Petrosino Teresa, Rinaldo Massimo, De Chiara Anna, Gallipoli Adolfo
Department of Diagnostic and Interventional Radiology, National Cancer Institute - Naples, Italy.
Anticancer Res. 2005 Jan-Feb;25(1B):595-9.
The aim of our study was to assess the color-Doppler ultrasound (CDU) pattern in the analysis of neoadjuvant preoperative treatment of patients with locally advanced breast carcinoma, improvement after injection of contrast medium (Levovist) and possible correlations between morphological and vascular aspects of the neoplasm and postoperative histopathological findings.
We studied 50 patients affected by locally advanced breast carcinoma (T3a e b-T4), using CDU before and after injection of Levovist, prior to and after neoadjuvant chemotherapeutic treatment.
The use of Levovist for ultrasound examinations prior to treatment revealed a higher number of vascular signals in 94% of the lesions compared to the basic color-Doppler examination; in only 3 cases (6%) were no modifications observed after injection of the contrast medium. This finding was also evident after neoadjuvant treatment, as a greater number of vessels in 28 lesions were observed, in addition to residual vascularization in 9 patients in whom the basic color-Doppler examination demonstrated substantial avascularity. Histopathology revealed that this method was more sensitive in disclosing the presence of active neoplastic tissue.
Color-Doppler ultrasound is the first step in assessing the efficacy of neochemotherapeutic treatment in patients affected by locally advanced breast carcinoma. Levovist increases sensitivity and improves the diagnostic precision, thus allowing for a better image of the vessels, which is an important index of the biological activity of the neoplasm, compared to the basic color-Doppler examination.
我们研究的目的是评估彩色多普勒超声（CDU）模式在局部晚期乳腺癌患者新辅助术前治疗分析中的应用，注射造影剂（声诺维）后的改善情况，以及肿瘤形态学和血管方面与术后组织病理学结果之间可能的相关性。
我们研究了50例局部晚期乳腺癌（T3a和b - T4）患者，在新辅助化疗前后分别于注射声诺维前后使用CDU进行检查。
与基础彩色多普勒检查相比，治疗前使用声诺维进行超声检查显示94%的病变中有更多的血管信号；注射造影剂后仅3例（6%）未观察到变化。新辅助治疗后这一发现也很明显，除了在基础彩色多普勒检查显示基本无血管的9例患者中有残余血管形成外，在28个病变中观察到更多的血管。组织病理学显示该方法在揭示活跃肿瘤组织的存在方面更敏感。
彩色多普勒超声是评估局部晚期乳腺癌患者新辅助化疗疗效的第一步。与基础彩色多普勒检查相比，声诺维提高了敏感性并改善了诊断准确性，从而能更好地显示血管图像，而血管是肿瘤生物活性的重要指标。
