p21WAF1/CIP1表达是口腔鳞状细胞癌预后不良的一个标志物。

p21WAF1/CIP1 expression is a marker of poor prognosis in oral squamous cell carcinoma.

作者信息

Nemes Judit A, Nemes Zoltán, Márton Ildikó J

机构信息

Faculty of Dentistry, Medical and Health Science Center, University of Debrecen, 4012 Debrecen, Hungary.

出版信息

J Oral Pathol Med. 2005 May;34(5):274-9. doi: 10.1111/j.1600-0714.2005.00310.x.

DOI:10.1111/j.1600-0714.2005.00310.x

PMID:15817070

Abstract

BACKGROUND

Previous research on the prognostic relevance of p21(WAF1/CIP1) in oral squamous cell carcinomas (OSCC) yielded inconclusive and contradictory data.

OBJECTIVES

To investigate the prognostic significance of p21(WAF1/CIP1) expression, its relationship to p53 accumulation, proliferation-associated proteins Ki-67 and cyclin D1 in relation to survival and clinicopathological features in OSCC.

METHODS

Surgical specimens taken from 106 randomly selected patients were studied by immunohistochemistry. Expression of the protein of interest was correlated with clinical data.

RESULTS

p21(WAF1/CIP1) expression was found in 61.3% of OSCCs. Expression of p21(WAF1/CIP1) significantly correlated with tumor size (P = 0.005), lymph node involvement (P = 0.002), clinical stage (P < 0.001), and tumor site (P = 0.002). Patients with tumors showing p21(WAF1/CIP1) immunopositivity had decreased 2-year survival (P = 0.018). Expression of p21(WAF1/CIP1) was not related to age, gender, risk factors (tobacco, alcohol), dental status, or tumor differentiation grade. The p21(WAF1/CIP1) expression positively correlated with proliferation-related variables Ki-67 (P = 0.010) and cyclin D1 (P < 0.001), but not with p53 expression.

CONCLUSIONS

The expression of p21(WAF1/CIP1) was found to be associated with poorer prognosis and tumor aggressivity in OSCC.

摘要

背景

先前关于p21（WAF1/CIP1）在口腔鳞状细胞癌（OSCC）中的预后相关性研究得出了不确定且相互矛盾的数据。

目的

探讨p21（WAF1/CIP1）表达的预后意义，及其与p53积累、增殖相关蛋白Ki-67和细胞周期蛋白D1在OSCC生存及临床病理特征方面的关系。

方法

对106例随机选取患者的手术标本进行免疫组织化学研究。将感兴趣蛋白的表达与临床数据相关联。

结果

在61.3%的OSCC中发现了p21（WAF1/CIP1）表达。p21（WAF1/CIP1）表达与肿瘤大小（P = 0.005）、淋巴结受累情况（P = 0.002）、临床分期（P < 0.001）和肿瘤部位（P = 0.002）显著相关。肿瘤显示p21（WAF1/CIP1）免疫阳性的患者2年生存率降低（P = 0.018）。p21（WAF1/CIP1）表达与年龄、性别、危险因素（烟草、酒精）、牙齿状况或肿瘤分化程度无关。p21（WAF1/CIP1）表达与增殖相关变量Ki-67（P = 0.010）和细胞周期蛋白D1（P < 0.001）呈正相关，但与p53表达无关。