Evaluation of a novel vaginal bromocriptine mesylate formulation: a pilot study.
作者信息
Darwish Atef M, Hafez Ehsan, El-Gebali Ibraheem, Hassan Saher B
机构信息
Department of Obstetrics and Gynaecology, Faculty of Medicine, Infertility Outpatient Clinic, Mother-Health Hospital, Assiut University, 71516 Assiut, Egypt.
出版信息
Fertil Steril. 2005 Apr;83(4):1053-5. doi: 10.1016/j.fertnstert.2004.09.024.
Abstract
Because of the frequent side effects found with oral bromocriptine, we created two formulas of vaginal bromocriptine suppositories to compare with vaginal application of bromocriptine tablets. The formula containing bromocriptine and a releasing agent (Pluronic F127) showed an increased dissolution rate, 39-fold greater than that of the pure drug alone, and subsequently was effective in lowering serum prolactin.
摘要
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