Bjerkeset Ottar, Nordahl Hans M, Mykletun Arnstein, Holmen Jostein, Dahl Alv A
HUNT Research Centre, Norwegian University of Science and Technology, Trondheim, Norway.
J Psychosom Res. 2005 Feb;58(2):153-61. doi: 10.1016/j.jpsychores.2004.07.011.
The aim of this study was to examine the impact of the first myocardial infarction (MI) and the relative influence of preexisting confounding factors on anxiety and depression in the following 5 years.
A total of 23,693 participants, 35-79 years of age at baseline, attended two population-based prospective studies in 1984-1986 and in 1995-1997. They underwent physical examination and self-reported demographic, lifestyle, psychosocial, and medical health characteristics in both surveys. Outcome measure was the Hospital Anxiety and Depression rating Scale (HADS).
Five hundred twelve participants suffered their first MI in the last 5 years before follow-up. Women showed an increased risk for both anxiety and depression in the first 2 years post-MI, followed by a significant symptom reduction. In contrast, the risk for depression in men increased after 2 years post-MI. Anxiety and depression, low educational level, obesity, daily smoking, and physical inactivity pre-MI significantly predicted a poor psychiatric outcome at follow-up.
Five-year follow-up after MI revealed gender-specific outcomes of anxiety and depression not previously described.
本研究旨在探讨首次心肌梗死（MI）的影响以及既往混杂因素对随后5年焦虑和抑郁的相对影响。
共有23693名参与者，基线年龄为35 - 79岁，参加了1984 - 1986年和1995 - 1997年的两项基于人群的前瞻性研究。他们在两次调查中均接受了体格检查，并自我报告了人口统计学、生活方式、心理社会和医疗健康特征。结局指标为医院焦虑抑郁量表（HADS）。
512名参与者在随访前的最后5年中首次发生心肌梗死。女性在心肌梗死后的前2年焦虑和抑郁风险增加，随后症状显著减轻。相比之下，男性在心肌梗死后2年抑郁风险增加。心肌梗死前焦虑和抑郁、低教育水平、肥胖、每日吸烟以及缺乏体育活动显著预测了随访时不良的精神结局。
心肌梗死后5年随访揭示了焦虑和抑郁的性别特异性结局，此前未被描述过。
Zotero 插件