人类中脑多巴胺与前额叶功能：COMT基因分型的相互作用与调节
Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype.
作者信息
Meyer-Lindenberg Andreas, Kohn Philip D, Kolachana Bhaskar, Kippenhan Shane, McInerney-Leo Aideen, Nussbaum Robert, Weinberger Daniel R, Berman Karen Faith
机构信息
Section on Integrative Neuroimaging, National Institute for Mental Health, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Bethesda, Maryland 20892-1365, USA.
出版信息
Nat Neurosci. 2005 May;8(5):594-6. doi: 10.1038/nn1438. Epub 2005 Apr 10.
Using multimodal neuroimaging in humans, we demonstrate specific interactions between prefrontal activity and midbrain dopaminergic synthesis. A common V(108/158)M substitution in the gene for catecholamine-O-methyltransferase (COMT), an important enzyme regulating prefrontal dopamine turnover, predicted reduced dopamine synthesis in midbrain and qualitatively affected the interaction with prefrontal cortex. These data implicate a dopaminergic tuning mechanism in prefrontal cortex and suggest a systems-level mechanism for cognitive and neuropsychiatric associations with COMT.
通过对人类进行多模态神经成像，我们证明了前额叶活动与中脑多巴胺能合成之间存在特定的相互作用。儿茶酚-O-甲基转移酶（COMT）是调节前额叶多巴胺转换的一种重要酶，其基因中常见的V（108/158）M替代预测中脑多巴胺合成减少，并在质量上影响与前额叶皮质的相互作用。这些数据表明前额叶皮质存在一种多巴胺能调节机制，并提示了一种与COMT相关的认知和神经精神关联的系统水平机制。
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