在羟基脲存在的情况下合成痘苗病毒多肽。
Synthesis of vaccinia virus polypeptides in the presence of hydroxyurea.
作者信息
Katz E, Margalith E, Winer B
出版信息
Antimicrob Agents Chemother. 1974 Nov;6(5):647-50. doi: 10.1128/AAC.6.5.647.
Abstract
Hydroxyurea (5 x 10(-3) M) inhibits the development of vaccinia virus in HeLa cells early after infection and prevents the synthesis of viral deoxyribonucleic acid. In the presence of hydroxyurea, late viral polypeptides are not formed, as observed by electrophoresis on polyacrylamide gels.
摘要
羟基脲（5×10⁻³ M）在感染后早期抑制痘苗病毒在HeLa细胞中的发育，并阻止病毒脱氧核糖核酸的合成。在羟基脲存在的情况下，如通过聚丙烯酰胺凝胶电泳观察到的，晚期病毒多肽未形成。
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