[缺氧诱导因子-1α在中耳胆脂瘤中的表达]
[Expression of hypoxia-inducible factor-1alpha in middle ear cholesteatoma].
作者信息
Liu Yang, Cui Yonghua, Yu Linlin, Zhang Ping
机构信息
Department of Otolaryngology, Tongji Hospital, Wuhan, 430030, China.
出版信息
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Jan;19(1):4-6.
OBJECTIVE
To explore the pathogenetic mechanism of middle ear cholesteatoma, the aim of this study is to detect the expression of Hypoxia-inducible factor-1alpha in middle ear cholesteatoma and normal external ear canal skin.
METHOD
We used the technology of immunohistochemistry to examine the expression of Hypoxia-inducible factor-1alpha in thirty-one middle ear cholesteatomas and ten samples of normal external ear canal skin.
RESULT
The expression of HIF-1alpha was extremely higher in middle ear cholesteatomas than in normal external ear canal skin (P <0.05).
CONCLUSION
We found that the higher expression of Hypoxia-inducible factor-1alpha in middle ear cholesteatomas, so we think that Hypoxia-inducible factor-1alpha play an important role in the pathogenetic process of middle ear cholesteatoma, and hypoxia may be an incentive in the pathogenetic mechanism of middle ear cholesteatoma.
目的
为探讨中耳胆脂瘤的发病机制，本研究旨在检测缺氧诱导因子-1α在中耳胆脂瘤及正常外耳道皮肤中的表达。
方法
采用免疫组织化学技术检测31例中耳胆脂瘤及10例正常外耳道皮肤样本中缺氧诱导因子-1α的表达。
结果
中耳胆脂瘤中HIF-1α的表达显著高于正常外耳道皮肤（P<0.05）。
结论
我们发现中耳胆脂瘤中缺氧诱导因子-1α表达较高，因此认为缺氧诱导因子-1α在中耳胆脂瘤的发病过程中起重要作用，缺氧可能是中耳胆脂瘤发病机制中的一个诱因。
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