Armour Katherine, Mann Stephen, Lee Stephen
Department of Dermatology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
Australas J Dermatol. 2005 May;46(2):70-5. doi: 10.1111/j.1440-0960.2005.00144.x.
The management of dysplastic naevi is a controversial subject. This study sought to assess the usefulness of the shave biopsy technique in the initial management of dysplastic naevi, and to demonstrate the advantages over the punch biopsy technique. We report a retrospective observational study of histopathology specimens examined in one histopathology practice over a 14-month period. Patients who had a clinical diagnosis of 'dysplastic naevus', which had initially been biopsied using either a shave or punch biopsy, and then followed up with a full-thickness elliptical excision, were included in the study. Histopathological concordance between the shave and punch biopsy specimens and their respective follow-up elliptical excisions was compared. We found that 21 of 22 (95.5%) shave biopsies were concordant with their respective excision specimens, and that 29 of 41 (70.7%) punch biopsies were concordant with their respective elliptical excision specimens. Of the shave biopsy specimens reviewed, 66% showed that the dysplastic naevi were completely excised with the initial biopsy, compared with 21.2% of the punch biopsy specimens. These findings confirm that shave biopsies provide accurate diagnostic information in the assessment of dysplastic naevi. Shave biopsies enable the entire lesion to be submitted for histopathological assessment, improving the chances of an accurate diagnosis.
发育异常痣的管理是一个有争议的话题。本研究旨在评估削切活检技术在发育异常痣初始管理中的实用性,并证明其相对于打孔活检技术的优势。我们报告了一项回顾性观察研究,对在一个组织病理学实践中14个月期间检查的组织病理学标本进行了研究。研究纳入了临床诊断为“发育异常痣”的患者,这些患者最初采用削切活检或打孔活检进行活检,然后进行全层椭圆形切除并随访。比较了削切活检标本和打孔活检标本与其各自后续椭圆形切除标本之间的组织病理学一致性。我们发现,22例削切活检中有21例(95.5%)与其各自的切除标本一致,41例打孔活检中有29例(70.7%)与其各自的椭圆形切除标本一致。在审查的削切活检标本中,66%显示发育异常痣通过初始活检被完全切除,而打孔活检标本的这一比例为21.2%。这些发现证实,削切活检在发育异常痣的评估中提供了准确的诊断信息。削切活检能够将整个病变送检进行组织病理学评估,提高了准确诊断的几率。