组织转谷氨酰胺酶抑制
Tissue transglutaminase inhibition.
作者信息
Keillor Jeffrey W
机构信息
Départment de Chimie, Université de Montréal, Québec H3C 3J7, Canada.
出版信息
Chem Biol. 2005 Apr;12(4):410-2. doi: 10.1016/j.chembiol.2005.04.001.
Abstract
Khosla and coworkers report the synthesis of peptidic dihydroisoxazole derivatives, the in vitro evaluation of these novel compounds as inhibitors of recombinant human tissue transglutaminase (TG2), and their oral bioavailability and efficacy for the synergistic treatment of glioblastoma tumors.
摘要
霍斯拉及其同事报告了肽类二氢异恶唑衍生物的合成、这些新型化合物作为重组人组织转谷氨酰胺酶（TG2）抑制剂的体外评估，以及它们对胶质母细胞瘤协同治疗的口服生物利用度和疗效。
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