丙型肝炎会加剧与艾滋病毒感染和甲基苯丙胺相关的认知缺陷。
Hepatitis C augments cognitive deficits associated with HIV infection and methamphetamine.
作者信息
Cherner M, Letendre S, Heaton R K, Durelle J, Marquie-Beck J, Gragg B, Grant I
机构信息
Department of Psychiatry, University of California San Diego, San Diego, CA 92103, USA.
出版信息
Neurology. 2005 Apr 26;64(8):1343-7. doi: 10.1212/01.WNL.0000158328.26897.0D.
OBJECTIVE
To examine the contribution of hepatitis C virus (HCV) infection to neurocognitive dysfunction in individuals with comorbid HIV infection or methamphetamine (METH) dependence.
METHODS
Neurocognitive functioning was examined in 430 study participants who were either normal controls or had HCV infection, HIV infection, history of METH dependence, or combinations of these factors as risks for cognitive deficits.
RESULTS
Rates of global and domain-specific neuropsychological (NP) impairment increased with the number of risk factors. HCV serostatus was a significant predictor of NP performance both globally and in the areas of learning, abstraction, and motor skills, with trends in speeded information processing and delayed recall. HCV serostatus did not predict scores in attention/working memory or verbal fluency.
CONCLUSION
Hepatitis C virus infection contributes to the neuropsychological deficits observed among HIV-infected and stimulant-dependent populations.
目的
探讨丙型肝炎病毒（HCV）感染对合并人类免疫缺陷病毒（HIV）感染或甲基苯丙胺（METH）依赖个体神经认知功能障碍的影响。
方法
对430名研究参与者的神经认知功能进行了检查，这些参与者要么是正常对照，要么患有HCV感染、HIV感染、有METH依赖史，或者这些因素的组合作为认知缺陷风险因素。
结果
整体和特定领域神经心理学（NP）损害的发生率随风险因素数量的增加而升高。HCV血清学状态是NP表现的显著预测因素，无论是整体还是在学习、抽象和运动技能方面，在快速信息处理和延迟回忆方面也有趋势。HCV血清学状态不能预测注意力/工作记忆或语言流畅性的得分。
结论
丙型肝炎病毒感染导致了在HIV感染和兴奋剂依赖人群中观察到的神经心理学缺陷。
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