微小RNA生物合成：协同裁剪与切割

MicroRNA biogenesis: coordinated cropping and dicing.

作者信息

Kim V Narry

机构信息

Department of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Seoul, 151-742, Korea.

出版信息

Nat Rev Mol Cell Biol. 2005 May;6(5):376-85. doi: 10.1038/nrm1644.

DOI:10.1038/nrm1644

PMID:15852042

Abstract

The recent discovery of microRNAs (miRNAs) took many by surprise because of their unorthodox features and widespread functions. These tiny, approximately 22-nucleotide, RNAs control several pathways including developmental timing, haematopoiesis, organogenesis, apoptosis, cell proliferation and possibly even tumorigenesis. Among the most pressing questions regarding this unusual class of regulatory miRNA-encoding genes is how miRNAs are produced in cells and how the genes themselves are controlled by various regulatory networks.

摘要

微小RNA（miRNA）的最新发现让许多人感到惊讶，因为它们具有非传统的特征和广泛的功能。这些微小的、约22个核苷酸的RNA控制着多种途径，包括发育时间、造血作用、器官发生、细胞凋亡、细胞增殖，甚至可能还包括肿瘤发生。关于这类不同寻常的编码miRNA的调控基因，最紧迫的问题之一是miRNA在细胞中是如何产生的，以及这些基因本身是如何被各种调控网络所控制的。