人巨细胞病毒感染中的US28作用：来自一个多功能劫持者的启示

US28 actions in HCMV infection: lessons from a versatile hijacker.

作者信息

Boomker J M, van Luyn M J A, The T H, de Leij L F M H, Harmsen M C

机构信息

Department of Pathology and Laboratory Medicine, Medical Biology Section, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.

出版信息

Rev Med Virol. 2005 Jul-Aug;15(4):269-82. doi: 10.1002/rmv.468.

DOI:10.1002/rmv.468

PMID:15861487

Abstract

Mimicking host proteins is a strategy adopted by several herpesviruses to exploit the host cell for their own benefit. In this respect the human cytomegalovirus (HCMV) chemokine receptor homologue US28, has been extensively studied. Molecular pirates such as US28 can teach us about crucial events in HCMV infection and may either offer a potential target for antiviral therapy or provide an alternative strategy to immune suppression. Despite elaborate research into the chemokine binding affinity, signalling properties, intracellular trafficking and expression kinetics of US28, a solid hypothesis about the role of US28 in HCMV infection has not yet been proposed. It appears that US28 may behave as a molecular pirate that employs smart strategies for cell entry, host gene regulation and immune evasion. This review will elaborate on these aspects of US28 biology and discuss possible implications for HCMV infection.

摘要

模仿宿主蛋白是几种疱疹病毒采用的一种策略，目的是为自身利益而利用宿主细胞。在这方面，人类巨细胞病毒（HCMV）趋化因子受体同源物US28已得到广泛研究。像US28这样的分子“海盗”可以让我们了解HCMV感染中的关键事件，并且可能为抗病毒治疗提供潜在靶点，或者提供一种免疫抑制的替代策略。尽管对US28的趋化因子结合亲和力、信号特性、细胞内运输和表达动力学进行了详尽研究，但尚未有人提出关于US28在HCMV感染中作用的可靠假说。看来，US28可能扮演着分子“海盗”的角色，采用巧妙策略实现细胞进入、宿主基因调控和免疫逃逸。本综述将详细阐述US28生物学的这些方面，并讨论其对HCMV感染可能产生的影响。