[Study of Qingciguo oil's function on blood lipid and other functions].

OBJECTIVE

To study Qingciguo Oil's function on blood lipid and other functions.

METHODS

84 male SD rats were randomly divided into seven groups (control group, high lipid group, low dose group, middle dose group, high dose group, combined dose group and combined control group) based on the level of TC. We respectively feed each group of rats with the normal food, high lipid high cholesterol food, Qingciguo Oil's 4 ml/kg BW food, Qingciguo Oil's 8 ml/kg BW food, Qingciguo Oil's 12 ml/kg BW food, Qingciguo Oil's 12 ml/kg BW + 0.8% soybean PL + 0.05% VitE food & 0.8% soybean PL + 0.05% VitE food ninth week.

RESULTS

At the fourth week, the TC of each group rats (except lower dose group) began to decreasing, and at sixth week, the TC of middle dose group was significantly lower than the high lipid group. At sixth week, the TG of low, middle and high dose group was significantly lower than the TG of high lipid group, the HDL of high lipid group and middle dose group decreased significantly, and the HDL of combined control dose group significantly higher than high lipid group. At the ninth week, the level of SOD of all experimental groups significantly higher than the high lipid group and the MDA of each group have no significant differents between each other. In vitro, we test the effect of different dose Qingciguo oil and fish oil on platelet aggragation of each blood by tuibidimetry, the results show that the platelet aggregation of Qingciguo oil high dose group was significantly lower than the control group.

CONCLUSION

Under our condition, Qingciguo oil has certain functions of decreasing the level of blood lipids modulating the function of antioxidants and restraining the platelet aggregation in vitro.