Adachi Sachika, Mochiduki Akikazu, Nemoto Haruki, Sun Binggui, Fujiwara Ken, Matsumoto Hirokazu, Inoue Kinji
Department of Regulation Biology, Faculty of Science, Saitama University, 255 Shimo-ohkubo, Sakura-ku, Saitama 338-0825, Japan.
Neurosci Lett. 2005 Jun 3;380(3):311-5. doi: 10.1016/j.neulet.2005.01.064. Epub 2005 Feb 12.
Prolactin-releasing peptide (PrRP) is known to be produced in A1/A2 noradrenergic neurons and to mediate the stress response. Our preliminary experiment showed that PrRP neurons in the A2 region differed between males and females in terms of c-Fos expression. In addition it has been reported that estrogen receptor alpha is detectable in A2 PrRP neurons. Therefore, we speculated that the stress response of PrRP neurons is modified by estrogen. We, therefore, examined c-Fos expression in A2 PrRP neurons during the estrous cycle and found that c-Fos accumulation in PrRP neurons was significantly decreased in estrus compared with in proestrus, metestrus and diestrus. This suggests that estrogen suppresses the activation of PrRP neurons. We thus administered diethylstilbestrol (DES) to ovariectomized rats and then added restraint stress. The data clearly showed that PrRP cells in DES-administered rats significantly suppressed c-Fos accumulation induced by stress.
催乳素释放肽（PrRP）已知在A1/A2去甲肾上腺素能神经元中产生，并介导应激反应。我们的初步实验表明，A2区域的PrRP神经元在c-Fos表达方面存在性别差异。此外，有报道称在A2 PrRP神经元中可检测到雌激素受体α。因此，我们推测PrRP神经元的应激反应会受到雌激素的调节。因此，我们检查了发情周期中A2 PrRP神经元中的c-Fos表达，发现与发情前期、发情后期和动情间期相比，发情期PrRP神经元中的c-Fos积累显著减少。这表明雌激素会抑制PrRP神经元的激活。因此，我们给去卵巢大鼠注射己烯雌酚（DES），然后施加束缚应激。数据清楚地表明，注射DES的大鼠中的PrRP细胞显著抑制了应激诱导的c-Fos积累。
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