发育中的软骨内骨骼中的成纤维细胞生长因子信号传导。
FGF signaling in the developing endochondral skeleton.
作者信息
Ornitz David M
机构信息
Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S. Euclid Ave., St. Louis, MO 63110, USA.
出版信息
Cytokine Growth Factor Rev. 2005 Apr;16(2):205-13. doi: 10.1016/j.cytogfr.2005.02.003. Epub 2005 Apr 1.
Abstract
Mutations in fibroblast growth factor receptors (Fgfrs) are the etiology of many craniosynostosis and chondrodysplasia syndromes in humans. The phenotypes associated with these human syndromes and the phenotypes resulting from targeted mutagenesis in the mouse have defined essential roles for FGF signaling in both endochondral and intramembranous bone development. In this review, I will focus on the role of FGF signaling in chondrocytes and osteoblasts and how FGFs regulate the growth and development of endochondral bone.
摘要
成纤维细胞生长因子受体（Fgfrs）的突变是人类许多颅缝早闭和软骨发育不全综合征的病因。与这些人类综合征相关的表型以及小鼠靶向诱变产生的表型，已明确了FGF信号传导在软骨内和成膜性骨发育中的重要作用。在这篇综述中，我将重点关注FGF信号传导在软骨细胞和成骨细胞中的作用，以及FGF如何调节软骨内骨的生长和发育。
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