Laughon S Katherine, Wolfe Honor M, Visco Anthony G
Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Obstet Gynecol. 2005 May;105(5 Pt 1):962-5. doi: 10.1097/01.AOG.0000158114.47925.fa.
To determine whether the increased risk of placenta previa at delivery in patients with a prior cesarean results from an increased risk of abnormal implantation or a lower likelihood of resolution.
A hospital-based, case-control study was performed. Cases were defined as singleton pregnancies with a placenta previa on second-trimester ultrasonography. Controls, chosen randomly from patients without a placenta previa on second-trimester ultrasonography, were matched 3:1 with cases. Odds ratios (OR) were calculated, controlling for other independent risk factors for previa: age, parity, race, and smoking.
There were 88 cases identified and 264 controls. Twenty cases (22.7%) and 35 controls (13.3%) had a history of prior cesarean delivery. Previous cesarean delivery was an independent risk factor for previa on second-trimester ultrasonography (OR 1.92, 95% confidence interval [CI] 1.04-3.55), as was the number of cesareans (OR 1.62, 95% CI 1.12-2.34). However, neither retained their significance after adjusting for other known risk factors for previa (OR 1.50, 95% CI 0.77-2.92, and OR 1.40, 95% CI 0.93-2.10, respectively). At delivery, a history of cesarean was associated with a 3-fold increased risk of previa.
A previous cesarean delivery did not increase the odds for detecting a placenta previa on second-trimester ultrasonography. At delivery, a previous cesarean was associated with a previa, suggesting a lower likelihood of resolution.
确定既往剖宫产患者分娩时前置胎盘风险增加是由于异常着床风险增加还是胎盘前置情况缓解可能性降低所致。
进行了一项基于医院的病例对照研究。病例定义为孕中期超声检查发现前置胎盘的单胎妊娠。对照组从孕中期超声检查未发现前置胎盘的患者中随机选取,病例与对照的比例为1:3。计算比值比(OR),并对前置胎盘的其他独立危险因素进行控制:年龄、产次、种族和吸烟情况。
共确定88例病例和264例对照。20例病例(22.7%)和35例对照(13.3%)有既往剖宫产史。既往剖宫产是孕中期超声检查发现前置胎盘的独立危险因素(OR 1.92,95%置信区间[CI] 1.04 - 3.55),剖宫产次数也是如此(OR 1.62,95% CI 1.12 - 2.34)。然而,在对前置胎盘的其他已知危险因素进行校正后,两者均不再具有统计学意义(分别为OR 1.50,95% CI 0.77 - 2.92和OR 1.40,95% CI 0.93 - 2.10)。分娩时,剖宫产史与前置胎盘风险增加3倍相关。
既往剖宫产并未增加孕中期超声检查发现前置胎盘的几率。分娩时,既往剖宫产与前置胎盘相关,提示胎盘前置情况缓解的可能性较低。