1,4-双（2'-氯乙基）-1,4-二氮杂双环-[2.2.1]庚烷顺丁烯二酸盐（达比斯顺丁烯二酸盐）对M5076及其对环磷酰胺耐药的亚系M5/CTX的抗肿瘤活性。
Antitumor activity of 1,4-bis (2'-chloroethyl)-1,4-diazabicyclo-[2.2.1] heptane dimaleate (Dabis Maleate) in M5076 and its subline resistant to cyclophosphamide M5/CTX.
作者信息
Tagliabue G, Filippeschi S, Hendricks H, D'Incalci M
机构信息
Istituto di Ricerche Farmacologiche M.Negri, Milan, Italy.
出版信息
Ann Oncol. 1992 Mar;3(3):233-6. doi: 10.1093/oxfordjournals.annonc.a058158.
We investigated the antitumoral activity of Dabis Maleate given on different dosage schedules and as continuous infusion in a murine reticular cell sarcoma M5076 (M5) and in a subline made resistant to cyclophosphamide and other nitrogen mustards (M5/CTX). The therapeutic index of Dabis Maleate was clearly better when the drug was given as a continuous 72-h infusion. Dabis Maleate appeared non-cross-resistant to cyclophosphamide and this property renders it interesting for further clinical development.
我们研究了马来酸达比司在不同给药方案下以及持续输注时对小鼠网状细胞肉瘤M5076（M5）和对环磷酰胺及其他氮芥耐药的亚系（M5/CTX）的抗肿瘤活性。当持续72小时输注该药物时，马来酸达比司的治疗指数明显更高。马来酸达比司似乎与环磷酰胺无交叉耐药性，这一特性使其在进一步的临床开发中具有吸引力。
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