促炎细胞因子白细胞介素-1β和白细胞介素-6在人胃癌进展中的作用。

Involvement of proinflammatory cytokines IL-1beta and IL-6 in progression of human gastric carcinoma.

作者信息

Kai Hirohisa, Kitadai Yasuhiko, Kodama Michiyo, Cho Songde, Kuroda Tsuyoshi, Ito Masanori, Tanaka Shinji, Ohmoto Yasukazu, Chayama Kazuaki

机构信息

Department of Medicine and Molecular Science, Hiroshima University, Graduate School of Biomedical Sciences, Hiroshima, Japan.

出版信息

Anticancer Res. 2005 Mar-Apr;25(2A):709-13.

PMID:15868900

Abstract

UNLABELLED

Gastric carcinoma occurs in response to chronic inflammation of gastric mucosa infected with Helicobacter pylori. It is not known how cytokines affect the growth and progression of gastric carcinoma.

MATERIALS AND METHODS

We measured tissue concentrations of the proinflammatory cytokines interleukin (IL)-1beta and IL-6 in gastric carcinoma and investigated the correlation between the levels of these cytokines and clinicopathological features. Biopsy specimens of tumors or adjacent normal mucosa were obtained from 42 Japanese patients with gastric carcinoma. Tissue levels of IL-1beta and IL-6 were measured by enzyme-linked immunosorbent assay.

RESULTS

IL-1beta levels were significantly higher in the neoplasm than in the corresponding normal mucosa. The IL-6 levels in the neoplasm correlated significantly with the depth of invasion and lymphatic invasion. High levels of IL-1beta and IL-6 were characteristic of non-scirrhous type gastric carcinoma.