在小鼠中创建体细胞遗传镶嵌体。

Cre-ating somatic cell genetic mosaics in the mouse.

作者信息

Anthony Todd E, Heintz Nathaniel

出版信息

Cell. 2005 May 6;121(3):322-3. doi: 10.1016/j.cell.2005.04.019.

DOI:10.1016/j.cell.2005.04.019

Abstract

Generation of somatic mosaics in which mutant cell clones are uniquely and completely labeled has yielded considerable insight into many biological processes in Drosophila. In this issue of Cell, describe a novel method called MADM that allows the generation of such mosaics in mice.

摘要

在果蝇中，生成其中突变细胞克隆被独特且完全标记的体细胞镶嵌体，已经为深入了解许多生物学过程提供了相当多的见解。在本期《细胞》杂志中，[作者]描述了一种名为MADM的新方法，该方法能够在小鼠中生成此类镶嵌体。