结节性硬化症患者癫痫手术候选者的识别
Identification of candidates for epilepsy surgery in patients with tuberous sclerosis.
作者信息
Lachhwani D K, Pestana E, Gupta A, Kotagal P, Bingaman W, Wyllie E
机构信息
Department of Neurology, The Cleveland Clinic Foundation, OH 44195, USA.
出版信息
Neurology. 2005 May 10;64(9):1651-4. doi: 10.1212/01.WNL.0000160389.93984.53.
The authors reviewed preoperative MRI and EEG findings in relation to postsurgical outcome in 17 patients with refractory epilepsy due to tuberous sclerosis complex (TSC). Resecting concordant MRI (main tuber) and EEG abnormalities offered seizure freedom (8/9, 89%; median follow-up 25 months) comparable to other focal etiologies. Patients with nonconcordant MRI and EEG findings did less well (3/8, 38%, seizure free; p = 0.027, OR = 13).
作者回顾了17例结节性硬化症（TSC）所致难治性癫痫患者术前MRI和脑电图（EEG）结果与术后结局的关系。切除与MRI（主要结节）和EEG异常一致的病灶可实现无癫痫发作（9例中的8例，89%；中位随访25个月），这与其他局灶性病因的情况相当。MRI和EEG结果不一致的患者预后较差（8例中的3例，38%无癫痫发作；p = 0.027，比值比=13）。
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