Cardoso João, Power Deborah, Clark Melody
CCMAR, Universidade do Algarve, Faro, Portugal.
Ann N Y Acad Sci. 2005 Apr;1040:257-60. doi: 10.1196/annals.1327.037.
In this study, members of family 2 GPCRs, one of the largest families of receptors in vertebrates, were isolated and characterized in the genome of the Japanese pufferfish, Fugu rubripes, and compared with the orthologous genes in other vertebrates. Phylogenetic analysis carried out with all vertebrate family 2 GPCR members indicated that CALR/CGRPR and CRF are the most divergent receptor group within this family and that the remaining members appear to originate from a common ancestral gene precursor.
在本研究中，对脊椎动物中最大的受体家族之一——2类G蛋白偶联受体（GPCRs）家族的成员进行了分离，并在日本河豚（红鳍东方鲀）的基因组中对其进行了表征，还与其他脊椎动物的直系同源基因进行了比较。对所有脊椎动物2类GPCR成员进行的系统发育分析表明，钙网蛋白/降钙素基因相关肽受体（CALR/CGRPR）和促肾上腺皮质激素释放因子（CRF）是该家族中差异最大的受体组，其余成员似乎起源于一个共同的祖先基因前体。
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