Gillette-Guyonnet Sophie, Lauque Sylvie, Ousset Pierre-Jean
Centre mémoire de ressource et de recherche, Toulouse, France.
Psychol Neuropsychiatr Vieil. 2005 Mar;3 Suppl 1:S35-41.
Weight loss is frequent in Alzheimer's disease. Its severity increases with the progression of the disease and may be a predictor of patients' mortality. Weight loss often precedes the diagnosis and may be considered as a feature of the disease itself. With the progression of the disease, disorders of eating behavior occur and result in weight loss and decreasing energy intake. Descriptive tools such as the Blandford Scale are helpful to assess eating disorders. Some hypotheses exist to explain the weight loss associated with Alzheimer's disease: atrophy of internal temporal cortex, increase of energy expenditure, biologic factors or modifications of body composition. Tools such as the Mini Nutritional Assessment allow assessment of nutritional status, diagnosis of malnutrition, cause identification and proposals for its correction. Patients' caregivers play a central role in prevention and management of nutritional disorders. Information programs for caregivers may reduce caregiver burden and improve patients' health status.
体重减轻在阿尔茨海默病中很常见。其严重程度随疾病进展而增加,可能是患者死亡率的一个预测指标。体重减轻往往在诊断之前就已出现,可能被视为该疾病本身的一个特征。随着疾病的进展,会出现饮食行为紊乱,导致体重减轻和能量摄入减少。像布兰德福德量表这样的描述性工具有助于评估饮食失调情况。存在一些假说来解释与阿尔茨海默病相关的体重减轻:颞叶内侧皮质萎缩、能量消耗增加、生物因素或身体成分改变。像微型营养评定这样的工具可以评估营养状况、诊断营养不良、确定病因并提出纠正建议。患者的照料者在营养失调的预防和管理中起着核心作用。针对照料者的信息项目可能会减轻照料者的负担并改善患者的健康状况。