硫氧还蛋白——结构与功能的复杂性

Thioredoxin - structural and functional complexity.

作者信息

Stefanková P, Kollárová M, Barák I

机构信息

Department of Biochemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina CH-1, 842 15 Bratislava 4, Slovakia.

出版信息

Gen Physiol Biophys. 2005 Mar;24(1):3-11.

PMID:15900083

Abstract

Thioredoxins are small globular proteins that proved to be excellent model for investigating the relationship between the structure of protein and their physico-chemical and functional properties. The results from the experiments on thioredoxins offer the basic for the development of the new paradigms in the field of chemistry, biophysics and biology of proteins, with special attention to redox reaction in living cells, protein stability and design. It is a good example of broad class of sulphur-containing redox proteins.

摘要

硫氧还蛋白是小型球状蛋白质，被证明是研究蛋白质结构与其物理化学性质及功能特性之间关系的极佳模型。对硫氧还蛋白的实验结果为蛋白质化学、生物物理学和生物学领域新范式的发展提供了基础，尤其关注活细胞中的氧化还原反应、蛋白质稳定性和设计。它是一大类含硫氧化还原蛋白的一个很好的例子。