采用氨苯砜和凝血因子 XIII 浓缩剂治疗的成人腹型过敏性紫癜伴严重腹痛

Adult Henoch-Schönlein purpura with severe abdominal pain treated with dapsone and factor XIII concentrate.

作者信息

Shimomura Naoko, Kawai Kazuhiro, Watanabe Shiro, Katsuumi Kaoru, Ito Masaaki

机构信息

Division of Dermatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Niigata 951-8510, Japan.

出版信息

J Dermatol. 2005 Feb;32(2):124-7. doi: 10.1111/j.1346-8138.2005.tb00729.x.

DOI:10.1111/j.1346-8138.2005.tb00729.x

PMID:15906543

Abstract

We describe an adult patient with Henoch-Schönlein purpura who had arthralgia, severe abdominal pain, and low plasma factor XIII activity. Corticosteroids were not used because of his history of multidrug-resistant pulmonary tuberculosis. Dapsone had no immediate effect on his abdominal pain, but appeared to have some effect on the purpura and arthralgia. Marked improvement of the abdominal pain was observed immediately after the administration of factor XIII concentrate. Factor XIII concentrate may be useful for alleviating abdominal pain in Henoch-Schönlein purpura patients when corticosteroids are contraindicated

摘要

我们描述了一名患有过敏性紫癜的成年患者，他有关节痛、严重腹痛和低血浆因子 XIII 活性。由于他有耐多药肺结核病史，未使用皮质类固醇。氨苯砜对他的腹痛没有立即起效，但似乎对紫癜和关节痛有一定效果。输注因子 XIII 浓缩物后立即观察到腹痛明显改善。当皮质类固醇禁忌时，因子 XIII 浓缩物可能有助于缓解过敏性紫癜患者的腹痛。