REST无休：REST/NRSF对神经发生的调控

No rest for REST: REST/NRSF regulation of neurogenesis.

作者信息

Lunyak Victoria V, Rosenfeld Michael G

机构信息

Department of Medicine, University of California, San Diego, Howard Hughes Medical Institute, La Jolla, California.

出版信息

Cell. 2005 May 20;121(4):499-501. doi: 10.1016/j.cell.2005.05.003.

DOI:10.1016/j.cell.2005.05.003

PMID:15907461

Abstract

Epigenetic strategies control the orderly acquisition and maintenance of neuronal traits. A complex network of transcriptional repressors and co-repressors mediates gene specificity for these strategies. In this issue of Cell, a study by Ballas and coworkers (Ballas et al., 2005) provides insight into the early lineage commitment events during neurogenesis. This study demonstrates that regulation of the REST/NRSF transcriptional repressor plays a fundamental role in the progression of pluripotent cells to lineage-restricted neural progenitors.

摘要

表观遗传策略控制着神经元特性的有序获得与维持。转录抑制因子和共抑制因子构成的复杂网络介导了这些策略的基因特异性。在本期《细胞》杂志中，巴拉斯及其同事的一项研究（巴拉斯等人，2005年）为神经发生过程中的早期谱系定向事件提供了见解。这项研究表明，REST/NRSF转录抑制因子的调控在多能细胞向谱系受限的神经祖细胞的转变过程中起着根本性作用。