肌肉生长抑制素，一种肌肉量的负调节因子：对肌肉退行性疾病的影响。
Myostatin, a negative regulator of muscle mass: implications for muscle degenerative diseases.
作者信息
Tobin James F, Celeste Anthony J
机构信息
Department of Cardiovascular and Metabolic Diseases, Wyeth Research, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, USA.
出版信息
Curr Opin Pharmacol. 2005 Jun;5(3):328-32. doi: 10.1016/j.coph.2005.01.011.
Myostatin is a secreted protein that negatively regulates skeletal muscle mass determining both muscle fiber number and size. The myostatin pathway is conserved and regulates muscle mass in a number of animal species ranging from fish to humans. Inhibition of myostatin using a variety of therapeutic approaches can increase muscle mass in a number of animal models of human disease, including muscular dystrophy.
肌生成抑制蛋白是一种分泌蛋白，它对骨骼肌质量起负调节作用，决定肌纤维的数量和大小。肌生成抑制蛋白信号通路是保守的，在从鱼类到人类等多种动物物种中调节肌肉质量。使用多种治疗方法抑制肌生成抑制蛋白，可以在包括肌肉萎缩症在内的多种人类疾病动物模型中增加肌肉质量。
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