Rung Johan P, Carlsson Arvid, Markinhuhta Katarina Rydén, Carlsson Maria L
The Arvid Carlsson Institute for Neuroscience, Institute of Clinical Neuroscience, The Sahlgrenska Academy, Göteborg University, Medicinaregatan 11, SE-405 30 Göteborg, Sweden.
Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jun;29(5):833-9. doi: 10.1016/j.pnpbp.2005.03.003.
Schizophrenia is manifested by positive and negative symptoms, as well as cognitive deficits. Most existing antipsychotic agents have poor effects on the negative symptoms of schizophrenia, thus emphasizing the necessity for developing new antipsychotic treatments. Dopaminergic stabilizers constitute one of the latest novelties in the quest for new antipsychotic drugs. Social withdrawal in rats, in response to treatment with NMDA-receptor antagonists such as (+)-MK-801, may be used to model negative symptoms. In this study we aimed to evaluate the dopaminergic stabilizers (-)-OSU6162 and ACR16, compared to haloperidol and clozapine, in a rat model for schizophrenia, focusing on (+)-MK-801 induced social withdrawal. Social behaviour and motor activity were assessed using a videotracking system, allowing automated analysis of the behaviour. Both (-)-OSU6162 and ACR16 were capable of restoring social behaviour, measured as proximity, to control level. These results indicate that these drugs may be effective in the treatments of negative symptoms.
精神分裂症表现为阳性和阴性症状以及认知缺陷。大多数现有的抗精神病药物对精神分裂症的阴性症状效果不佳，因此强调开发新的抗精神病治疗方法的必要性。多巴胺能稳定剂是寻求新型抗精神病药物的最新创新之一。大鼠对NMDA受体拮抗剂如（+）-MK-801治疗的社交退缩可用于模拟阴性症状。在本研究中，我们旨在评估多巴胺能稳定剂（-）-OSU6162和ACR16与氟哌啶醇和氯氮平相比，在精神分裂症大鼠模型中的作用，重点关注（+）-MK-801诱导的社交退缩。使用视频跟踪系统评估社交行为和运动活动，以便对行为进行自动分析。（-）-OSU6162和ACR16都能够将以接近程度衡量的社交行为恢复到对照水平。这些结果表明这些药物可能对阴性症状的治疗有效。
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