竹红菌素B单体钌配合物的合成与表征
Synthesis and characterization of the monomer ruthenium complex of hypocrellin B.
作者信息
Zhou Jiahong, Liu Jihua, Feng Yuying, Wei Shaohua, Gu Xiaotian, Wang Xuesong, Zhang Baowen
机构信息
Analysis and Testing Center, Nanjing Normal University, Nanjing 210097, China.
出版信息
Bioorg Med Chem Lett. 2005 Jun 15;15(12):3067-70. doi: 10.1016/j.bmcl.2005.04.035.
PMID:15913997
Abstract
We first synthesized and characterized a monomer ruthenium complex of hypocrellin B (HB) by chelation with Ru(bpy)2Cl2 (in which bpy=2,2'-bipyridine). It possesses the photosensitizing properties and can be applied in photodynamic therapy (PDT). The chemiluminescence assays indicated that the photodamage ability of the complex is stronger than that of HB.
摘要
我们首先通过与Ru(bpy)2Cl2（其中bpy = 2,2'-联吡啶）螯合合成并表征了单体竹红菌素B（HB）钌配合物。它具有光敏特性，可应用于光动力疗法（PDT）。化学发光分析表明，该配合物的光损伤能力比HB更强。
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