Wang Helen Y, Wang Rong-Fu
ALKEK Building, N1120, Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
Microbes Infect. 2005 Jun;7(7-8):1056-62. doi: 10.1016/j.micinf.2005.03.028. Epub 2005 Apr 25.
Regulatory T cells play essential roles in inducing self-tolerance by suppressing immune responses against self such as autoantigens or non-self-antigens such as tumor and pathogenic antigens. Despite the importance of CD4(+) regulatory T cells in many immune-related diseases, their antigen specificity and suppressive mechanisms remain elusive. This review discusses the natural ligands and their potential roles of tumor-specific CD4(+) regulatory T cells in cancer therapy.
调节性T细胞在诱导自身耐受中发挥着重要作用，通过抑制针对自身的免疫反应，如自身抗原，或针对非自身抗原，如肿瘤和病原性抗原。尽管CD4(+)调节性T细胞在许多免疫相关疾病中具有重要性，但其抗原特异性和抑制机制仍不清楚。这篇综述讨论了肿瘤特异性CD4(+)调节性T细胞的天然配体及其在癌症治疗中的潜在作用。
