Raaphorst Frank M
Department of Pathology, VU Medical Center, 1081 HV Amsterdam, The Netherlands.
Int J Hematol. 2005 May;81(4):281-7. doi: 10.1532/IJH97.05023.
Genes belonging to the Polycomb group (PcG) are responsible for the maintenance of cell identity and are directly involved in epigenetic gene silencing. They perform a vital role in the regulation of embryogenesis but also contribute to various adult processes, including regulation of the cell cycle and lymphopoiesis. Experimental model systems have demonstrated that enhanced expression of individual PcG genes, such as Bmi1, results in the development of B-cell and T-cell lymphomas. In humans, a growing body of work has now linked human PcG genes to various hematologic and epithelial cancers. This review focuses on the emerging role of PcG genes in the development of human malignant lymphomas.
属于多梳蛋白家族（PcG）的基因负责维持细胞特性，并直接参与表观遗传基因沉默。它们在胚胎发育调控中发挥着至关重要的作用，同时也参与多种成年期生理过程，包括细胞周期调控和淋巴细胞生成。实验模型系统已证明，个别PcG基因（如Bmi1）的表达增强会导致B细胞和T细胞淋巴瘤的发生。在人类中，越来越多的研究工作现已将人类PcG基因与各种血液系统和上皮性癌症联系起来。本综述重点关注PcG基因在人类恶性淋巴瘤发生中的新作用。
