Ohsawa Masaki, Okayama Akira, Nakamura Motoyuki, Onoda Toshiyuki, Kato Karen, Itai Kazuyoshi, Yoshida Yuki, Ogawa Akira, Kawamura Kazuko, Hiramori Katsuhiko
Department of Hygiene and Preventive Medicine, School of Medicine, Iwate Medical University, Morioka, Iwate 020-8505, Japan.
Prev Med. 2005 Aug;41(2):651-6. doi: 10.1016/j.ypmed.2005.02.002.
It is not clear whether there is a dose-response relationship between the number of cigarettes smoked per day and CRP level and whether there is a relationship between the length of smoking cessation and CRP level.
Geometric mean levels of CRP were compared in smoking status groups for 1926 men aged 40 to 69 years using analysis of covariance.
After adjusting for several confounding factors, geometric mean levels of CRP (mg/L) were significantly different among the three smoking status groups (0.41 in non-smokers, 0.57 in current smokers, 0.48 in past smokers, P < 0.05). A linear trend was not found in the relationship between CRP level and number of cigarettes smoked per day. The mean CRP level in the long cessation (> or =5 years) group was significantly lower than that in the short cessation (<5 years) group (0.45 vs. 0.58, P < 0.05) and similar to that in the non-smokers group (0.45 vs. 0.41, NS).
CRP levels in current smokers are elevated but unrelated to the number of cigarettes smoked per day. In past smokers, long-term smoking cessation may contribute to the reduction in risk of development of cardiovascular diseases through inflammatory mechanisms.
目前尚不清楚每日吸烟量与CRP水平之间是否存在剂量反应关系，以及戒烟时长与CRP水平之间是否存在关联。
采用协方差分析比较了1926名40至69岁男性吸烟状态组中CRP的几何平均水平。
在调整了几个混杂因素后，三个吸烟状态组的CRP几何平均水平（mg/L）存在显著差异（非吸烟者为0.41，当前吸烟者为0.57，既往吸烟者为0.48，P<0.05）。未发现CRP水平与每日吸烟量之间存在线性趋势。长期戒烟（≥5年）组的平均CRP水平显著低于短期戒烟（<5年）组（0.45对0.58，P<0.05），且与非吸烟者组相似（0.45对0.41，无显著性差异）。
当前吸烟者的CRP水平升高，但与每日吸烟量无关。在既往吸烟者中，长期戒烟可能通过炎症机制有助于降低心血管疾病发生风险。
