[不同明暗周期对小鼠学习记忆的影响]
[Effects of different light-dark cycle on learning and memory in mice].
作者信息
Liu Yan-you, Yang Bo, Jiang Zhou, Guo Li, Wang Yue-qi, Wang Zheng-rong
出版信息
Space Med Med Eng (Beijing). 2004 Oct;17(5):381-2.
OBJECTIVE
To study the effect of different light-dark cycles on learning and memory in mice.
METHOD
Seventy-two ICR mice were raised under different light-dark cycles including LD 5h/5h, LD 12h/12h and LD 22h/22h for 6 weeks. The locomotor activity was recorded continuously. Morris water-maze task was used as the judging criteria for spatial learning and memory.
RESULT
The locomotor activity rhythm was consistent with the light-dark cycle. The period of light-dark cycle shorter than 24 h such as 10 h could effect on the ability of learning and memory in mice.
CONCLUSION
The short period of light-dark cycle can improve the ability of learning and memory in mice.
目的
研究不同光暗周期对小鼠学习记忆的影响。
方法
将72只ICR小鼠在不同光暗周期（包括LD 5h/5h、LD 12h/12h和LD 22h/22h）下饲养6周。持续记录其运动活动。采用Morris水迷宫任务作为空间学习记忆的评判标准。
结果
运动活动节律与光暗周期一致。短于24小时的光暗周期如10小时可影响小鼠的学习记忆能力。
结论
短光暗周期可提高小鼠的学习记忆能力。
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