具有5'-取代吡咯烷硫基作为C-2侧链的新型青霉烯化合物；其生物学性质与碳青霉烯类化合物的比较
New penem compounds with 5'-substituted pyrrolidinylthio group as a C-2 side chain; comparison of their biological properties with those of carbapenem compounds.
作者信息
Sunagawa M, Matsumura H, Inoue T, Fukasawa M
机构信息
Research Laboratories, Sumitomo Pharmaceuticals Co., Ltd., Osaka, Japan.
出版信息
J Antibiot (Tokyo). 1992 Apr;45(4):500-4. doi: 10.7164/antibiotics.45.500.
PMID:1592682
Abstract
A series of new penem compounds with a C-2 side chain consisting of a pyrrolidin-3'-ylthio group substituted with various aminocarbonyl groups at the C-5' position have been prepared. Antibacterial activity, stability to renal dehydropeptidase-I and affinity to penicillin-binding proteins of these compounds were investigated and compared with the corresponding carbapenem compounds.
摘要
已制备出一系列新的青霉烯化合物，其C-2侧链由在C-5'位被各种氨基羰基取代的吡咯烷-3'-硫基组成。研究了这些化合物的抗菌活性、对肾脱氢肽酶-I的稳定性以及对青霉素结合蛋白的亲和力，并与相应的碳青霉烯化合物进行了比较。
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