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Licensing for DNA replication requires a strict sequential assembly of Cdc6 and Cdt1 onto chromatin in Xenopus egg extracts.
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Recombinant Cdt1 induces rereplication of G2 nuclei in Xenopus egg extracts.
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Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus.
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ATP hydrolysis by ORC catalyzes reiterative Mcm2-7 assembly at a defined origin of replication.
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Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts.
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Loss of rereplication control in Saccharomyces cerevisiae results in extensive DNA damage.
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Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control.
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Molecular structure of human geminin.
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