Germano Carmela, Kinsella Glynda J
School of Psychological Science, La Trobe University, Bundoora VIC 3086, Australia.
Neuropsychol Rev. 2005 Mar;15(1):1-10. doi: 10.1007/s11065-005-3583-7.
Cognitive deficits associated with early Alzheimer's disease (AD) have been recently operationalised in terms of an acquisition deficit and the research supporting this view is presented. However, there is still debate concerning the nature of this deficit and how underlying cognitive processes may be detrimentally affecting the ability to acquire new information in early AD. This review argues that the pattern of cognitive deficits contributing to the acquisition impairment in early AD patients may be readily interpreted within the context of a working memory model. Isolating the component processes of working memory that underlie the acquisition deficit in early AD patients will aid in the design of clinical applications that are focussed at enhancing the ability to acquire new information in everyday life.
与早期阿尔茨海默病（AD）相关的认知缺陷最近已根据获取缺陷进行了界定，并展示了支持这一观点的研究。然而，关于这种缺陷的本质以及潜在的认知过程如何对早期AD患者获取新信息的能力产生不利影响，仍存在争议。本综述认为，在工作记忆模型的背景下，可以很容易地解释导致早期AD患者获取障碍的认知缺陷模式。分离出早期AD患者获取缺陷背后的工作记忆组成过程，将有助于设计旨在提高日常生活中获取新信息能力的临床应用。
