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贲门失弛缓症的腹腔镜Heller-Toupet手术结果。

Results of laparoscopic Heller-Toupet operation for achalasia.

作者信息

Perrone J M, Frisella M M, Desai K M, Soper N J

机构信息

Washington University Institute for Minimally Invasive Surgery, St. Louis, MO 63110, USA.

出版信息

Surg Endosc. 2004 Nov;18(11):1565-71. doi: 10.1007/s00464-004-8912-z. Epub 2004 Oct 11.

Abstract

BACKGROUND

Laparoscopic myotomy has become the preferred treatment for achalasia. Controversy persists on the need for fundoplication and/or its type; when used, most series have utilized the Dor fundoplication. We report a large series of laparoscopic Heller-Toupet procedures.

METHODS

All patients operated for achalasia were entered into a prospective database. Pre and postoperative esophageal symptoms, satisfaction scores, and SF-36 variables were compared. Surgical failures were defined as recurrent or persistent dysphagia leading to secondary treatment. Data are expressed as mean +/- S.D.

RESULTS

One hundred consecutive cases were analyzed (61 men, 39 women, age 47 +/- 17 yr). Heller-Toupet was performed in 94, whereas six patients had a Dor fundoplication because of mucosal perforation (three) or technical difficulties performing a posterior wrap (three). Operative time was 148 +/- 21 min. There were 13 intraoperative adverse events managed laparoscopically, and no conversions. Minor postoperative complications were noted in two cases, whereas there were no major complications or deaths. Mean hospital stay was 1.2 +/- 0.5 days, (range 1-4). Follow-up was complete in 92% at 26 +/- 17 months. Failures leading to further treatment occurred in 4%. All symptom scores were significantly improved (p < 0.0001). Solid dysphagia score went from 6.4 to 1.0 postoperatively; regurgitation score went from 4.5 to 0.2 (combined frequency and severity, range 0-8). Postoperative global esophageal symptoms scale revealed improvement in 97%, and all domains of the SF-36 were improved.

CONCLUSIONS

Although the best surgical approach to achalasia is yet to be determined, laparoscopic Heller-Toupet operation in experienced hands is a safe and effective procedure with low rates of morbidity and failure and high patient satisfaction.

摘要

背景

腹腔镜下肌层切开术已成为贲门失弛缓症的首选治疗方法。对于是否需要进行胃底折叠术和/或其类型仍存在争议;在使用胃底折叠术时,大多数系列研究采用的是Dor胃底折叠术。我们报告了一系列大量的腹腔镜Heller-Toupet手术。

方法

所有接受贲门失弛缓症手术的患者均被纳入前瞻性数据库。比较术前和术后的食管症状、满意度评分以及SF-36变量。手术失败定义为复发性或持续性吞咽困难导致二次治疗。数据以平均值±标准差表示。

结果

连续分析了100例病例(61例男性,39例女性,年龄47±17岁)。94例患者接受了Heller-Toupet手术,而6例患者因黏膜穿孔(3例)或进行后壁包裹时遇到技术困难(3例)接受了Dor胃底折叠术。手术时间为148±21分钟。有13例术中不良事件通过腹腔镜处理,无中转开腹情况。术后有2例出现轻微并发症,无严重并发症或死亡病例。平均住院时间为1.2±0.5天(范围1 - 4天)。在26±17个月时,92%的患者完成随访。导致进一步治疗的失败率为4%。所有症状评分均显著改善(p < 0.0001)。固体食物吞咽困难评分从术前的6.4降至术后的1.0;反流评分从4.5降至0.2(综合频率和严重程度,范围0 - 8)。术后食管整体症状量表显示97%的患者症状改善,SF-36的所有领域均有所改善。

结论

尽管贲门失弛缓症的最佳手术方法尚未确定,但在经验丰富的医生手中,腹腔镜Heller-Toupet手术是一种安全有效的手术,发病率和失败率低,患者满意度高。

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