[卵巢癌患者中TRAIL、TRAIL-R（DR4、DcR1）和Fas-L的表达]
[The expression of TRAIL, TRAIL-R (DR4, DcR1) and Fas-L in patients with ovarian cancer].
作者信息
Li Chun-mei, Peng Zhi-lan, Yang Kai-xuan
机构信息
Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu 610041, China.
出版信息
Sichuan Da Xue Xue Bao Yi Xue Ban. 2005 May;36(3):341-3.
OBJECTIVE
To investigate the apoptosis induced by TRAIL, TRAIL-R and Fas-L in patients
METHODS
The expression of TRAIL, TRAIL-R (DR4,DcR1) and Fas-L in ovarian cancer was detected with immunohistochemistry.
RESULTS
The levels of DR4 and DcR1 expression in ovarian carcinoma with ovarian carcinoma were lower than that of normal tissues. The positive rate of DR4 in well-differentiated ovarian carcinoma was significantly higher than that in poorly differentiated ovarian carcinoma (92.31% vs 54.55%, P < 0.05). The expression of TRAIL was significantly correlated with that of Fas-L (r = 0.777).
CONCLUSION
The expressions of DR4 and DcR1 are lower than that of normal tissues, and the expression of DR4 might be a prognostic factor in ovarian cancer.
目的
研究肿瘤坏死因子相关凋亡诱导配体（TRAIL）、TRAIL受体（TRAIL-R）和Fas配体（Fas-L）在患者中诱导的细胞凋亡情况。
方法
采用免疫组织化学法检测卵巢癌组织中TRAIL、TRAIL-R（DR4、DcR1）和Fas-L的表达。
结果
卵巢癌组织中DR4和DcR1的表达水平低于正常组织。高分化卵巢癌中DR4的阳性率显著高于低分化卵巢癌（92.31%对54.55%，P<0.05）。TRAIL的表达与Fas-L的表达显著相关（r=0.777）。
结论
DR4和DcR1的表达低于正常组织，DR4的表达可能是卵巢癌的一个预后因素。
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