Razak Albiruni Ryan Abdul, Nasser Qasiem, Morris Patrick, Alcutt David, Grogan Liam
Department of Medical Oncology, Beamont Hospital, Dublin, Ireland.
J Neurooncol. 2005 May;73(1):89-90. doi: 10.1007/s11060-004-4209-2.
A 24-year old primaparous female at 20 weeks gestation presented acutely with cerebellar symptoms. Magnetic resonance imaging brain showed evidence of a cerebellar vermis lesion. This was diagnosed as medulloblastoma on histopathological analysis. She underwent surgical debulking and radiotherapy. Interestingly, the lesion recurred 4 years later on her second pregnancy. She underwent further surgical debulking and adjuvant chemotherapy. We believe this is the first reported description of recurrent medulloblastoma in successive pregnancies. A brief discussion on this disease and its management in pregnancy setting is also presented.
一名24岁初产妇,孕20周时急性出现小脑症状。脑部磁共振成像显示小脑蚓部有病变。经组织病理学分析诊断为髓母细胞瘤。她接受了手术减瘤和放疗。有趣的是,4年后她再次怀孕时病变复发。她又接受了进一步的手术减瘤和辅助化疗。我们认为这是首次报道的连续妊娠中复发性髓母细胞瘤的病例。本文还对该疾病及其在妊娠情况下的治疗进行了简要讨论。