[Significance of MMP2 and MMP9 expression in prostate cancer].
作者信息
Zhang Xiao-Yi, Hong Bao-Fa, Chen Guang-Fu, Lu Ya-Li, Zhong Mei
机构信息
Department of Urology, China PLA General Hospital, Beijing 100853, China.
出版信息
Zhonghua Nan Ke Xue. 2005 May;11(5):359-61, 364.
PMID:15934460
Abstract
OBJECTIVE
To evaluate the significance of the expression of matrix metalloproteinases (MMPs) in prostate cancer (PCa) and its clinical association.
METHODS
Fifty one cases of PCa and 10 cases of BPH were studied by immunohistochemical method using monoclonal antibodies to MMP2 and MMP9.
RESULTS
There was significant correlation between MMP2 or MMP9 and pathological grade, Gleason score and PCa metastasis.
CONCLUSION
The expression of MMP2 and MMP9 may play an important role in the development and metastasis of PCa.
摘要
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