晚期肾细胞癌的黑暗天空会很快放晴吗？

Will the dark sky over advanced renal cell carcinoma soon become brighter?

作者信息

D'Hondt V, Gil T, Lalami Y, Piccart M, Awada Ahmad

机构信息

Clinic of Medical Oncology, Institut Jules Bordet, Bd de Waterloo 125, Brussels 1000, Belgium.

出版信息

Eur J Cancer. 2005 Jun;41(9):1246-53. doi: 10.1016/j.ejca.2004.11.025.

DOI:10.1016/j.ejca.2004.11.025

PMID:15939260

Abstract

Until recently, immunotherapy has been the most efficient treatment for advanced renal cell carcinoma, but clinical results are largely unsatisfactory. More promising agents are being developed as a result of an improved understanding of the biology of the disease. Several agents that target known biological abnormalities of the disease are now being tested in the clinic. This review describes the encouraging clinical results obtained to date with these new drugs or combinations of drugs.

摘要

直到最近，免疫疗法一直是晚期肾细胞癌最有效的治疗方法，但临床结果在很大程度上并不令人满意。由于对该疾病生物学的认识有所提高，正在研发更有前景的药物。目前有几种针对该疾病已知生物学异常的药物正在临床中进行测试。这篇综述描述了迄今为止使用这些新药或药物组合所取得的令人鼓舞的临床结果。